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Chaos and Pain

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This Ain’t Your Grandpa’s DHEA

DHEA… along with Androstenadione, it was the supplement credited with getting people Sammy Sosa-waddling-around-the-field-jacked just after steroids were criminalized in 1990. For anyone who took it then, it was scarfed down in handfuls because its bioavailability was so low, and the results basically ranged from nonexistent to minor placebo effect. Frankly, I only knew it as something people claimed to use to throw people off the trail when they were using steroids, or something occasionally sold to the elderly to improve longevity. As such, I was never keen on it, and when the new DHEA products started popping up, I had the type of healthy skepticism one usually reserves for conspiracy theories involving reptilian aliens, statements linking vegetarianism and good mental health, or claims that Orange is the New Black is watchable.

DHEA from 1994 was just as shitty and expensive as that year’s laptops were.

It seems that although skepticism regarding DHEA in the past was completely valid, comparing the DHEA of 1994 with the DHEA of 2017 is like comparing laptops of 1994 with laptops of today. Hell, even shitty phones have two and a half orders of magnitude more computing power than those hyper-expensive doorstops had. In the same way, compounds like 4-DHEA and 1-DHEA blow old-school DHEA out of the water like they hit it with a nuclear depth charge, especially because products like Chemical Four and Chemical One utilize a liposomal delivery system that drastically improves the delivery of both prohormones by allowing them to bypass your body’s natural defense mechanisms. That wasn’t even possible in the 1990s, as medical science was still working on ways to maximize the effectiveness of liposomal delivery, and no one in the supplement industry had even considered using a lipid layer in encapsulated products to improve their absorption.

At this point, you might be wondering exactly what it is that 4-DHEA and 1-DHEA actually do… and the answer to that is pretty simple. They convert to testosterone to aid in gaining muscle mass and physical strength, though their side effects are far less ridiculous than what people were seeing out of designer steroids like Superdrol. Both 4- and 1-DHEA go through a two step conversion process from their original compound to testosterone, which for any of you who used 4-AD and 1-Testosterone before they were banned in 2005, the end result is the same. For 4-DHEA, it converts first into 4-AD (the aforementioned banned prohormone) and then to testosterone with little to no estrogenic sides, which means that it’ll get people over the plateaus they might hit from training without steroids. If you want to know how badass your results will be using 4-DHEA, just google 4-AD and check out what kind of results people got before the ban- in any product with a liposomal delivery system like Chemical Four, the rate of absorption goes through the roof and the results will be nearly identical. This means using 4-DHEA is going to produce the lean gains and strength increases that you’re going to need if you plan on destroying the opposition in competition or just stealing dude’s girlfriends by using nothing more than a casual flex at the bar one Friday night. And don’t pretend you’re not pulling casual flexes all night at the bar. We know better.

That just leaves 1-DHEA, which is essentially a rabid dire wolf in comparison to old school DHEA’s sickly Chihuahua. 1-DHEA converts to 1-Testosterone, a compound that had researchers shitting their pants ten years ago because it worked as well as testosterone propionate and was still floating around on the supplement market after it was banned in 2005. As you’d expect from anything that androgenic and anabolic, 1-DHEA is not without side effects, but expecting massive muscle growth with no side effects whatsoever would be like taking a bunch of Adderall and expecting it to come without your heart hammering out of your chest and the occasional bout of diarrhea. So, 1-DHEA isn’t for the faint of heart or prohormone noobs- you need to know what you’re doing with 1-DHEA in re controlling aromatization and post-cycle therapy, but you needn’t worry that your liver will fall out like you had to with the methylated chemical nightmares of the early 2000s.


Where’s this leave us? Old school DHEA has provided inconsequential evidence of hypertrophy and strength gains, even in the elderly, and if you can’t put muscle on a person who’s wasting away while waiting to shuffle off their mortal coil in some backwoods old folk’s home, you probably can’t put muscle on anyone. In sharp contrast, 1-DHEA is a precursor to a compound that had scientists screaming for the law to shut down every prohormone maker on the market ten years ago because it kicked so much ass, and 4-DHEA is the kinder, gentler version of that. Throw into the mix cutting edge techniques developed by big pharma to turn their drugs into hyper-efficient chemical snipers, and you’ve got a couple of winners on your hands. It’s a brave new world in supplementation, and we’re reaping the benefits. Check out Chemical One and Chemical Four for more information on these badass compounds, and then go forth and conquer.


Androdiol – Hi-Tech’s Liposomal Legal 4-DHEA Anabolic. PricePlow. 16 Feb 2016. Web. 29 May 2016.

Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Thevis M, Vollmer G, Zierau O, Diel P. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties. Toxicol Lett. 2006 Aug 20;165(2):149-55. Epub 2006 Apr 18.

Pogue. 1-Andro / 1-Androsterone / 1-DHEA: Everything to Know. Priceplow. 27 Mar 2016. Web. 29 May 2017.

Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S. Advances and Challenges of Liposome Assisted Drug Delivery. Frontiers in Pharmacology. 2015;6:286.

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